Click and hear Paul G. Richardson present the data for the combination therapy with elotuzumab in combination pomalidomide and dexamethasone for relapsed/refractory multiple myeloma. Elotuzumab, an immunostimulatory monoclonal antibody targeting SLAMF7, enables selective killing of MM cells through multiple mechanisms of action and synergizes with the immunomodulatory drug pomalidomide. This study demonstrated sustained and clinically relevant PFS and OS benefits for elotuzumab plus pomalidomide and dexamethasone vs pomalidomide in combination with dexamethasone, with no new safety signals. These data support the long-term favorable efficacy–safety profile of elotuzumab plus pomalidomide and dexamethasone and suggest this regimen could be considered as a standard of care for patients with relapsed/refractory multiple myeloma after failure of lenalidomide and a proteasome inhibitor.

Despite recent advances in MM therapy, the disease remains incurable. Patients with late-stage RRMM refractory to pomalidomide and/or daratumumab have limited effective treatment options. Melflufen is a novel peptide-conjugated alkylator potentiated by intracellular aminopeptidases, which are markedly overexpressed in multiple myeloma. In this MEDtalk Paul G. Richardson present updated efficacy and safety of melflufen + low-dose dexamethasone in patients refractory to pomalidomide and/or daratumumab (HORIZON-study).

The SAM domain and HD domain 1 (SAMHD1) protein is a deoxynucleoside triphosphate (dNTP) triphosphohydrolase, which has been initially described to restrict human immunodeficiency virus type 1 (HIV-1) in the immune cells. This study shows that SAMHD1 is expressed in approximately half of de novo diffuse large B-cell Lymphomas at a variable level and correlates with cell of origin (GC), biomarkers of tumor aggressiveness (eg MYC, proliferation) and clinical outcome.

MEST SETE MEDtalks

Chronic Lymphocytic Leukaemia - Upfront Treatment   Se hele webinar

Chronic Lymphocytic Leukaemia – Upfront Treatment

<script src="https://fast.wistia.com/embed/medias/x9hmg3bo4e.jsonp" async></script><script src="https://fast.wistia.com/assets/external/E-v1.js" async></script><div class="wistia_responsive_padding" style="padding:56.25% 0 0 0;position:relative;"><div class="wistia_responsive_wrapper" style="height:100%;left:0;position:absolute;top:0;width:100%;"><div class="wistia_embed wistia_async_x9hmg3bo4e seo=false videoFoam=true" style="height:100%;position:relative;width:100%"><div class="wistia_swatch" style="height:100%;left:0;opacity:0;overflow:hidden;position:absolute;top:0;transition:opacity 200ms;width:100%;"><img src="https://fast.wistia.com/embed/medias/x9hmg3bo4e/swatch" style="filter:blur(5px);height:100%;object-fit:contain;width:100%;" alt="" onload="this.parentNode.style.opacity=1;" /></div></div></div></div>
Chronic Lymphocytic Leukaemia - Upfront Treatment&nbsp;&nbsp;&nbsp;<a href='https://bestprac.no/webinar/chronic-lymphocytic-leukaemia-upfront-treatment/'>Se hele webinar
Chronic Lymphocytic Leukaemia - Upfront Treatment

ASH 2018: Nytt om myelomatose fra ASH 2018

<script src="https://fast.wistia.com/embed/medias/joiuej08zx.jsonp" async></script><script src="https://fast.wistia.com/assets/external/E-v1.js" async></script><div class="wistia_responsive_padding" style="padding:56.25% 0 0 0;position:relative;"><div class="wistia_responsive_wrapper" style="height:100%;left:0;position:absolute;top:0;width:100%;"><div class="wistia_embed wistia_async_joiuej08zx seo=false videoFoam=true" style="height:100%;position:relative;width:100%"><div class="wistia_swatch" style="height:100%;left:0;opacity:0;overflow:hidden;position:absolute;top:0;transition:opacity 200ms;width:100%;"><img src="https://fast.wistia.com/embed/medias/joiuej08zx/swatch" style="filter:blur(5px);height:100%;object-fit:contain;width:100%;" alt="" onload="this.parentNode.style.opacity=1;" /></div></div></div></div>
ASH 2018: Nytt om myelomatose fra ASH 2018&nbsp;&nbsp;&nbsp;<a href='https://bestprac.no/webinar/ash-2018-nytt-om-myelomatose-fra-ash-2018/'>Se hele webinar
Nytt om myelomatose fra ASH 2018

ASH 2018: Efficacy and Safety of Ponatinib in CML and Ph+ ALL Patients – in Real-World Clinical Practice

<script src="https://fast.wistia.com/embed/medias/kbs3mjg440.jsonp" async></script><script src="https://fast.wistia.com/assets/external/E-v1.js" async></script><div class="wistia_responsive_padding" style="padding:56.25% 0 0 0;position:relative;"><div class="wistia_responsive_wrapper" style="height:100%;left:0;position:absolute;top:0;width:100%;"><div class="wistia_embed wistia_async_kbs3mjg440 seo=false videoFoam=true" style="height:100%;position:relative;width:100%"><div class="wistia_swatch" style="height:100%;left:0;opacity:0;overflow:hidden;position:absolute;top:0;transition:opacity 200ms;width:100%;"><img src="https://fast.wistia.com/embed/medias/kbs3mjg440/swatch" style="filter:blur(5px);height:100%;object-fit:contain;width:100%;" alt="" onload="this.parentNode.style.opacity=1;" /></div></div></div></div>
ASH 2018: Efficacy and Safety of Ponatinib in CML and Ph+ ALL Patients – in Real-World Clinical Practice&nbsp;&nbsp;&nbsp;<a href='https://bestprac.no/webinar/ash-2018-efficacy-and-safety-of-ponatinib-in-cml-and-ph-all-patients-in-real-world-clinical-practice/'>Se hele webinar
ASH 2018: Efficacy and Safety of Ponatinib in CML and Ph+ ALL Patients – in Real-World Clinical Practice

ASH 2018: Venetoclax-Rituximab kombinasjonen hos pasienter med tilbakefall /refraktær KLL (R/R CLL). Oppdatering på MURANO-studien

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ASH 2018: Venetoclax-Rituximab kombinasjonen hos pasienter med tilbakefall /refraktær KLL (R/R CLL). Oppdatering på MURANO-studien&nbsp;&nbsp;&nbsp;<a href='https://bestprac.no/webinar/ash-2018-venetoclax-rituximab-combination-therapy-in-relapsed-refractory-cll-update-data-from-murano-study/'>Se hele webinar
ASH 2018: Venetoclax-Rituximab kombinasjonen hos pasienter med tilbakefall /refraktær KLL (R/R CLL). Oppdatering på MURANO-studien

In this MEDtalk Stine Mikkelsen present the first study investigating submicroscopic copy number variations/ uniparental disomy in idiopathic cytopenia of undetermined significance patients. In a subset of patients with otherwise no detectable genetic abnormalities, Stine Mikkelsen and colleagues identified structural variations involving genes recurrently affected in MDS. Their results suggest that SNP-A can aid the prognostics of ICUS patients by identifying submicroscopic structural variations as risk markers for poor OS.

TOURMALINE-MM3 is a phase 3, double-blind, placebo-controlled study, where ixazomibimproved PFS, and is the first study to evaluate the impact ofmaintenance therapyon quality of life in postautologous stem cell transplant in newly diagnosed multiple myeloma. In this MEDtalk Fredrik Schjesvold present the data from the study showing, that active treatment with ixazomibdid not have an adverse impact on HRQoL.

The Nordic Myeloma Study Group (NMSG) initiated the CARFI trial, an open randomized phase II study, to investigate the efficacy and safety of carfilzomib as part of induction and conditioning in salvage ASCT and to evaluate the role of carfilzomib/dexamethasone maintenance after salvage ASCT. In this MEDtalk Henrik Gregersen report that maintenance therapy with carfilzomib and dexamethasone maintenance prolongs median time to progression with approximately 6 months following salvage ASCT in multiple myeloma.

Kommende EventKommende Event

Juni 21, 2019 19:00

ICML 2019, LUGANO NORDIC HIGHLIGHTS EVENING

Onkologi /hematologi

meld deg på her

ASH 2018

ASCO 2018

EHA 2018

#Siste magasin

Onkologi / Hematologi

Nr. 42 • mars 2019
9. Årgang
  • Brystkreft
  • Malignt melanom
  • Genomsekvensering
#

Onkologi /hematologi

Anders Waage,

Anders Waage,
Overlege, Professor II

Daniel Heinrich,

Daniel Heinrich,
Overlege

Erik Skaaheim Haug,

Erik Skaaheim Haug,
Overlege, dr.med.

Jan Oldenburg,

Jan Oldenburg,
MD, ph.d., overlege

Jürgen Geisler,

Jürgen Geisler,
Professor, dr.med., dr. philos.

Odd Terje Brustugun,

Odd Terje Brustugun,
Overlege, dr.med.

Åse Bratland,

Åse Bratland,
Overlege, ph.d.,
fagansvarlig overlege